Creative Biolabs Announces Optimized Custom Oligonucleotide Synthesis Service
Apr 12, 2022
New York City, New York Apr 12, 2022 (Issuewire.com) - Since the first RNA interference (RNAi) therapy, Patisiran, was approved in 2018, RNAi technology catches more attention. And advanced treatments like this are replacing traditional cancer treatment approaches such as chemotherapy. However, scientists may confront several difficulties, such as the unstable and potentially immunogenic nature of RNA and the costly expense.
With an industry-leading portfolio of services and regulatory expertise, Creative Biolabs pays attention to the latest drug development programs by endogenous RNAi machinery and offers a total solution containing every step of RNAi therapy discovery. Recently, the portfolio of custom oligonucleotide synthesis services is updated to cover more types of complex oligonucleotides.
- Custom miRNA Synthesis
Creative Biolabs is ready to support miRNA-based therapeutics studies with custom miRNA synthesis services, including fast protein expression by injecting or transfecting mRNA into cells and regulatory miRNA study through profiling, overexpression, or knockdowns.
* miRNA expression: chemical synthesis and lentiviral vector-based expression to allow optimization of knockdown by synthetic miRNAs
* Hairpin architecture: a custom design for the high knockdown efficiency
* Concatenation strategy: natural polycistronic miRNA backbones, concatenation of several synthetic miRNA hairpins, DROSHA-independent intronic miRNA
- Custom siRNA Synthesis
Creative Biolabs is dedicated to providing custom siRNA synthesis services using online design tools and extensive synthesis options for specific applications. Now, the team has built a series of worry-free customizations for siRNA synthesis based on clients' sequences or sequences designed at clients' requests.
* Custom siRNA Design: free online design tools for customized projects
* Modifications & Labeling: a full range of modifications and fluorescent labels
* Product Processing Options: HPLC purified, desalted single strand, desalted duplex strands, siRNA in-vivo-ready
- Custom mRNA Synthesis
Scientists at Creative Biolabs are skillful in manufacturing research-grade or GMP-grade mRNAs and provide tailored synthesis at milligram to multigram scales, with lengths ranging from a few hundred nucleotides to more than 10 kilobases.
The service covers the whole workflow from the synthesis of the gene, plasmid cloning and purification, full DNA sequencing documentation, PCR amplification of insert and PCR products purification, mRNA synthesis by in vitro transcription, to purification and quality control (QC).
More custom synthesis services are available for miRNA inhibitor, ssRNA, bridged nucleic acid, plate oligonucleotide, degenerated oligo, etc. Find more information on the official website https://www.creative-biolabs.com/gene-therapy/.
About Creative Biolabs
With years of experience in providing one-stop preclinical development services, Creative Biolabs has built a team of experts with solid knowledge of gene therapy, and is fully competent in providing services for worldwide clients. The services include but are not limited to delivery vehicles development, gene editing, RNAi therapy development, safety and toxicology analysis, potency tests, and solutions of specific gene therapy development for diseases.
Source :Creative Biolabs
This article was originally published by IssueWire. Read the original article here.
More News
Experience Kissimmee Launches Film Kissimmee
Experience Kissimmee announces the launch of Film Kissimmee, the official film commission for Osceola County. The commission is created to attract film, television, commercial and digital media productions, showcase the destination’s diverse filming locations and expand opportunities for the local tourism economy. Film Kissimmee will serve as a central resource for production companies, location managers and digital content creators seeking filming opportunities in Central Florida. The initiative connects industry professionals with a wide range of filming locations, local expertise and production resources to help bring stories to life in Osceola County.
Meet Nathan Fielder, who co-directed the Elizabeth Holmes documentary, You Can See Everything
If there’s one name Hollywood cannot stop raving about this autumn, it’s Nathan Fielder. The 43-year-old Canadian comedian is behind the hit new Elizabeth Holmes documentary, You Can See Everything, released on October 16, which earned an impressive US$15 million at the North American box office in its opening weekend. Fielder co-directed the A24 production with Lance Oppenheim after the disgraced Theranos founder and CEO and her long-time partner, Billy Evans, invited them to their rented Del...
British Airways Wins Big in European Awards
British Airways is returning to its former glory it seems, scooping four titles in this year's awards The post British Airways Wins Big in European Awards appeared first on Business Traveller.
This Airline has the Best Economy and Premium Economy Cabins in Europe
In this year's awards, the German flag carrier has won both best economy and premium economy class in Europe, among other titles The post This Airline has the Best Economy and Premium Economy Cabins in Europe appeared first on Business Traveller.
Qatar Airways Named World’s Best Frequent Flyer Programme
Clarity, flexibility and rewards worth chasing: why Qatar Airways Privilege Club leads the field. The post Qatar Airways Named World’s Best Frequent Flyer Programme appeared first on Business Traveller.
Suite by Aspire at Zurich Airport Claims Top Spot
If you're passing through Zurich Airport, make sure to visit Suite by Aspire, crowned Europe’s Best Third-Party Lounge in this year’s awards The post Suite by Aspire at Zurich Airport Claims Top Spot appeared first on Business Traveller.
Emirates Sets the Global Benchmark Across Three Cabin Classes
Emirates takes the spotlight with global recognition across First Class, Premium Economy and Economy The post Emirates Sets the Global Benchmark Across Three Cabin Classes appeared first on Business Traveller.
London Heathrow Crowned Best Airport in Europe
The London hub stands out for its fast immigration clearance and some of Europe’s best airline lounges The post London Heathrow Crowned Best Airport in Europe appeared first on Business Traveller.
Mandarin Oriental Wins Best City Hotel Brand in the World
Landmark buildings, local experiences and a sense of place set Mandarin Oriental apart, from London and New York to Istanbul. The post Mandarin Oriental Wins Best City Hotel Brand in the World appeared first on Business Traveller.
Cathay Pacific Wins Big in the Skies and on the Ground
From cabin upgrades to lounge access and Asia Miles redemptions, Cathay Pacific’s award-winning offer spans the airport and the flight The post Cathay Pacific Wins Big in the Skies and on the Ground appeared first on Business Traveller.
The Winners of the 2026 Business Traveller Awards Have Been Announced
Find out who took the top spot in the Business Traveller Awards 2026, across the global and regional categories The post The Winners of the 2026 Business Traveller Awards Have Been Announced appeared first on Business Traveller.
Aman Resorts Named World’s Leading Luxury Resort Brand
Our pick for best resort brand in the world, Aman puts serenity first, in settings from Utah’s desert to the turquoise waters of Palawan. The post Aman Resorts Named World’s Leading Luxury Resort Brand appeared first on Business Traveller.
YOUR NEWS, OUR NETWORK.
Do you have Great News you want to tell the world?
Be it updates about your business or your community, you can make sure that it’s heard by submitting your story to our network reaching hundreds of news sites across 6 verticals.